Lilly tests therapy to rid brain plaques in mice with Alzheimer’s

(Reuters) – Drugmaker Eli Lilly & Co said it may have found a way to remove plaque from the brains of forgetful, old mice using an experimental therapy it hopes someday will be used to treat Alzheimer’s disease in humans.

Previous animal studies have demonstrated that it is possible to prevent the formation of brain plaques, which are thought to be a hallmark of the progressive memory-robbing disease. But until now, researchers have not been able to remove pre-existing plaques, made of amyloid beta protein, once they have deposited into the brain, Lilly said.

These deposited plaques are insoluble, whereas soluble forms of amyloid beta are free-floating around the brain and have been easier to target.

Lilly researchers developed a genetically engineered antibody that selectively targets insoluble plaques and was able to cross the blood-brain barrier. The antibody was then able to bind itself to the deposited amyloid beta, and clear roughly 50 percent of pre-existing plaques in the mice without causing damage to tiny vessels in the brain.

“We’re very enthused about understanding the mechanism and science behind it,” lead researcher Ronald DeMattos said in a telephone interview. “We don’t know how it translates in humans until we test human antibodies in clinical trials.”

Indeed, there have been scores of mice that were cured of cancer and other diseases with experimental drugs that did not work in humans.

But Lilly is excited about this study because, at least in mice, a new therapeutic approach for Alzheimer’s disease appears to be viable.

DeMattos said the drugmaker, which is developing other Alzheimer’s drugs, is already engineering a human antibody that will target insoluble plaques. He said he expects the company to begin clinical trials using this antibody within a year.

Results of the study, entirely funded by Lilly, were published in the journal Neuron on Wednesday.

Lilly’s best known Alzheimer’s disease drug is solanezumab, a medicine given by infusion that attacks amyloid beta protein. In data presented in August, the drug failed in large clinical trials to arrest cognitive and physical declines among patients with mild to moderate Alzheimer’s. But it was shown to somewhat delay cognitive declines in patients with mild symptoms.

(Additional reporting Ransdell Pierson; Editing by Nick Zieminski)

(This story corrects timeline paragraph eight to start clinical trials to one year.)

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Microsoft #DroidRage Tweet Shows How Malware Has Moved Past Windows

“Do you have an Android malware horror story?” Microsoft asks through its @windowsphone Twitter account, in what may be one of the most ironic tweets of the year.

After all, it wasn’t that long ago that “virus” and “worm” stories made headlines on a regular basis, all of them about “computer viruses” which were really Windows viruses. Just a few years ago, Apple advertised the fact that a Mac “Doesn’t get PC viruses” as a reason to buy one.

But this year, 600,000 Macs were infected by the Flashback trojan, an epidemic which exceeded the scale of history’s single largest Windows infection. And now ​Microsoft​ is implying that its phones don’t get malware, as a way to advertise them. How did things get to be this way, and what will malware and virus authors do next?

​When virii attack

For years, Microsoft’s DOS and Windows operating systems were the biggest targets for virus and malware authors simply because they were the least secure. Today’s PC security best practices had yet to be built into them, and trying to bolt features on to ancient programming code was a half-baked solution at best. HugeWindows malware epidemics spread as the malware programs were able to install themselves without explicit permission and operate without user intervention.

​Network effects

One reason Microsoft Windows dominated the computing world for years and years was simply because it was dominant. More people using Windows meant more profits for Windows app developers, which meant more games and apps for Windows, which meant more people buying Windows PCs so they could use Windows games and apps.

Like with apps, malware is a business that makes money for the people who write it. And while it was theoretically possible to infect a computer running a more secure operating system, like OS X (used on Macs) or Ubuntu (powered by Linux), it was considered impossible to get it to spread far enough to be profitable. Whereas on Windows it was (and still is) possible to infect vast numbers of PCs, even chaining them into zombified “botnets” which act as supercomputers-for-hire.

​How the mighty have fallen?

OS X’s more secure design makes it extremely hard to infect with malware — normally. The Flashback trojan sneaked in this year using the Java web browser plugin, which is bundled with the Mac’s Safari web browser and was poorly maintained.

Plugins like Java and Flash open up new ways to infect a computer, which was one reason why Apple stopped including the Flash plugin (already absent on its iPhone and iPad) by default. Apple created a fix for the problem, but not before over half a million Macs were infected.

​What about on smartphones?

Unlike Apple and Microsoft’s app stores, the Google Play store allows anyone to submit anything with no review. It’s up to Android smartphone and tablet users to look at the “permissions” each game or app requests, as well as the reputation of their developers, and decide whether or not to install them.

While some consider this approach more “trustworthy” and respectful of users, it’s also helped lead to a comparatively enormous number of malware infections on Android, including “The Mother of All Android Malware,” which completely took over tens of thousands of phones last year.

​Are you #DroidRage-ing yet?

Microsoft’s tweet says “we may have a get-well present” for people who send it their best or worst stories of Android malware. Even if all the apps in the Windows Store are virus-free, however, there are still far fewer of them than there are for Android.

Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.
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White House preps Plan B if debt talks fail

White House press secretary Jay Carney (Charles Dharapak/AP)President Barack Obama's budget office is preparing for the possibility that "fiscal cliff" talks will fail, triggering painful automatic cuts to domestic and defense programs that he and his Republican foes officially want to avoid. White House press secretary Jay Carney described the planning as an abundance of caution, not pessimism about the seemingly stalled negotiations.

The White House's Office of Management and Budget this week "issued a request to federal agencies" for information needed to finalize calculations on the spending cuts required under what is technically known as "sequestration," Carney told reporters at his daily briefing. OMB is "acting responsibly," he added.

"The administration remains focused on reaching agreement, as we've been discussing, on a balanced deficit-reduction plan that avoids sequestration" he said. "This action should not be read … as a change in the administration's commitment to reach an agreement and avoid sequestration."Leaders of both parties have pledged to work together in the coming weeks, and we are confident, as I just said, that we can reach an agreement. However, with less than one month left before a potential sequestration order would have to be issued, the Office of Management and Budget must take certain steps to ensure the administration is ready to issue such an order should Congress fail to act."

Carney's comments came as talks on the fiscal cliff—a series of tax hikes and government spending cuts that could plunge the economy into a new recession—seemed to be making no headway. Obama and congressional Republicans have each put a proposal on the table but do not appear to be actively involved in negotiating a compromise. The president and Republican House Speaker John Boehner spoke by telephone, a House Republican aide said. They spoke "this afternoon—no other information," the aide said.

"If our offer is not acceptable to the president, then he has an obligation to show leadership by presenting a credible plan of his own that can pass both houses of Congress," Boehner said earlier. He accused Obama of snubbing spending cuts he accepted in the past (notably in failed 2011 negotiations) and failing to lay out "serious spending cuts."

"This is preventing us from reaching an agreement," Boehner continued. "With the American economy on the brink of the fiscal cliff, we don't have time for the president to continue shifting the goal posts. We need to solve this problem."

Obama, meanwhile, flatly dismissed the idea that Republicans might use next year's vote on raising the country's debt limit as leverage in current fiscal cliff negotiations, saying it won't be entertained by the White House.

While talks between Obama and Boehner appeared to be in a deep freeze, the president and congressional leaders met separately with top executives of the Business Roundtable association in Washington. A BRT official said the group met with Republican House Majority Whip Kevin McCarthy, then Democratic Senate Finance Committee Chairman Max Baucus and Republican Sen. John Thune, who sits on the Finance and Budget committees.

BRT Chairman Jim McNerney, president and CEO of Boeing, described the discussion with Obama as "candid and constructive" and the chat with congressional leaders as "constructive."

He noted that "we encourage both sides to work around the clock, if necessary, to avoid the severe repercussions that inaction would have on U.S. economic growth and job creation."

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WestJet embraces tech to woo business travelers

TORONTO (Reuters) – WestJet Airlines Ltd will use technological innovation, including a new Internet ticket booking system, to help it transform from a no-frills carrier to a lower-cost full-service airline courting lucrative corporate travelers, its chief executive said on Monday.

Canada’s second-biggest airline plans to launch a series of technology systems, most notably the new online booking engine, which will sell three tiers of tickets, in the next two months.

“Companies evolve or they die,” Chief Executive Gregg Saretsky told Reuters in a phone interview from the company’s Calgary head office.

“We’re 16 and going on 17 years old and we can’t stay just as we were 17 years ago. The world has changed. And we are changing to be more relevant for a broader segment of guests.”

The new Internet booking system, which WestJet hopes to launch in late January, will sell economy, mid-tier and premium tickets. That is a major shift from its current system, which sells only the lowest-priced ticket available.

Economy tickets under the new system will continue to sell the lowest available fare, but the cancellation fee for them will jump to C$ 75 ($ 75.48) from C$ 50. Mid-tier tickets will have a C$ 50 cancellation fee.

Premium tickets, unavailable until late March when WestJet finishes reconfiguring its 100 Boeing 737 planes to allow more leg room, will include priority screening and boarding, free cancellations and flexibility on ticket changes.

Pricing for those tickets, which may include free meals and drinks and an extra baggage allowance, has not yet been determined. Fares will be well below half the price for business class at WestJet’s bigger competitor, Air Canada, Saretsky said.

“It’s time for us to be more serious with respect to going after business travelers because frankly, they’re the ones who are booking last-minute and are happy to pay for the conveniences,” Saretsky said.

WestJet will launch its premium economy service with 24 seats per plane, but will consider expansion if it proves “wildly successful,” he added.

POISED FOR CHANGE

WestJet, which has spent about C$ 40 million over the past two years on technology projects, is poised for major changes in 2013 as it readies to launch a new regional airline, Encore.

Saretsky hopes that WestJet’s switch in coming weeks to a new Internet phone system will allow ticket reservation agents to work from home and help make room for Encore staff.

Some 750 reservation agents work at WestJet’s Calgary offices, which house about 2,400 staff. Space will be needed for Encore employees over the next 18 months while their office, hangars and maintenance stores are constructed at the WestJet campus.

Encore will be launch in the second half of 2013, “probably closer to July than December,” Saretsky said, with seven Bombardier Q400 planes.

While WestJet won’t announce Encore’s schedule until Jan 21, the carrier will initially serve only “a handful” of new cities, with ticket prices up to 50 percent below Air Canada’s, he added.

Over the next two months, WestJet will also roll out a guest notification system that alerts travelers via email about their flights, allowing them to check in remotely.

Such self-service technology will be critical as WestJet faces increasing labor costs, Saretsky said.

Wage and benefit costs, which represent about a third of operating costs, have climbed 50 percent since WestJet was founded in 1996.

“You can see that creates a little bit of drag on earnings,” Saretsky said. “We’ve got to find ways of reducing our component costs.”

If WestJet can increase self service options for travelers, that could limit the need for new employees, Saretsky said. Management also wants to improve attendance management, so that fewer employees book off sick around long weekends, and more quickly clean and process planes between flights, he said.

(Reporting By Susan Taylor; Editing by Peter Galloway)

(This story was corrected to show that WestJet is replacing its Internet booking engine, not entire reservation system, in the first and second paragraphs)

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Disney loses appeal of “Who Wants to Be a Millionaire?” ruling

LOS ANGELES (Reuters) – The Walt Disney Co. was ordered to pay the British creator of the television game show “Who Wants to be a Millionaire?” $ 319 million after a Los Angeles court rejected the company’s request for a new trial.

Britain’s Celador International, which created the quiz show, sued Disney in 2004 alleging that the company hid some of the show’s U.S. profits from Celador.

A three-judge panel of the 9th U.S. Circuit Court of Appeals in Pasadena ruled on Monday that the lower court’s judgment was neither excessive nor based on speculation of profits owed.

A 2010 jury trial found that Disney and its domestic syndication company, Buena Vista Television, owed Celador $ 269.2 million and a federal judge added $ 50 million in interest.

“We are extremely disappointed with the decision, as ABC and Buena Vista Television continue to believe that they fully adhered to the ‘Millionaire’ agreement,” Walt Disney said in a statement on Tuesday.

Disney did not comment on further possible legal action.

“Who Wants to Be a Millionaire?” aired on Disney-owned broadcaster ABC from 1999 to 2002 and was credited with ushering in a new era of reality programming on U.S. television.

“I am pleased that justice has been done,” Celador Chairman Paul Smith said in a statement.

The game show, which started in Britain and later became an international hit, quizzes contestants on trivia for the top prize of $ 1 million. The show is now in U.S. syndication.

(Reporting by Eric Kelsey, editing by Jill Serjeant)

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Flu Season Begins Earliest in a Decade

Flu season 2012-13 has begun in the United States, according to Dr. Thomas Friedan, director of the Centers for Disease Control and Prevention . The good news: The vaccine available for the season matches up well with the flu already being reported. This information, coupled with the fact that there are ample flu shots to go around, bodes well for those who have been immunized and for those wanting to be immunized against this season’s most likely flu virus culprits.

Early Flu Season 2012

Friedan participated in a telebriefing on Monday, explaining that reports from physicians in several states points to an increase of patients seeking treatment for flu-like symptoms and that most of those cases will likely turn out to be influenza. Unlike the flu season of 2011-12, which had a late start, this season has begun the earliest since 2003.

Both Friedan and Dr. Melinda Wharton, acting director of the National Center for Immunization and Respiratory Diseases, emphasized that peak flu season is generally seen in the months of January and February, allowing plenty of time to get the flu shot now and develop immunity to the strains protected by the immunization.

A “Flu View” map provided by the CDC, updated weekly with the most current information, shows that five states are already experiencing high levels of flu activity: Texas, Louisiana, Mississippi, Alabama and Tennessee, with Georgia and and Missouri each reporting moderate flu activity.

National Influenza Vaccination Week Dec. 2-8

In an effort to encourage people to take the flu vaccine, the CDC has embarked on a concentrated effort to educate the public on both influenza and its prevention. Although some people may think it’s too late to take the flu shot, the CDC and the U.S. Surgeon General’s office want you to know that getting a flu shot now may save you and/or your family from the flu and its possible complications, including hospitalization and even death. An average of 24,000 people in the United States dies each year from flu complications.

People who are at higher risk for developing complications from the flu include children age 5 years and younger — and especially children under 2 years of age and those under 6 months of age. Also included in the high risk categories for flu complications are pregnant women, people with chronic conditions such as lung problems, diabetes and heart disease. People age 65 and older, baby boomers and seniors, are also more likely to develop serious complications from the flu.

Where You Can Find the Flu Shot

An interactive map allows you to find the places nearby that are offering flu vaccinations and answers questions you may have about the vaccine and the various administration options.

Bottom Line

Approximately 112 million people have already taken the flu shot, according to estimates by the National Center for Immunization and Respiratory Diseases. The immunization is the single best way to protect you and your family from this season’s influenza. Even if you are not concerned about yourself becoming ill, give consideration to those about whom you care and protect them from the flu, and worse.

Smack dab in the middle of the baby boomer generation, L.L. Woodard is a proud resident of “The Red Man” state. With what he hopes is an everyman’s view of life’s concerns both in his state and throughout the nation, Woodard presents facts and opinions based on common-sense solutions.

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32% of Young People Use Social Media in the Bathroom

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GOP leaders pluck conservative lawmakers, reveal growing divide

WASHINGTON (AP) — House Speaker John Boehner's decision to take plum committee assignments away from four conservative Republican lawmakers after they bucked party leaders on key votes isn't going over well with advocacy groups that viewed them as role models.

Reps. Tim Huelskamp of Kansas and Justin Amash of Michigan will lose their seats on the House Budget Committee chaired by Rep. Paul Ryan next year. And Reps. Walter Jones of North Carolina and David Schweikert of Arizona are losing their seats on the House Financial Services Committee.

The move is underscoring a divide in the Republican Party between tea party-supported conservatives and the House GOP leadership.

"This is a clear attempt on the part of Republican leadership to punish those in Washington who vote the way they promised their constituents they would — on principle — instead of mindlessly rubber-stamping trillion dollar deficits and the bankrupting of America," said Matt Kibbe, president of the tea party group FreedomWorks.

Michael Steel, a spokesman for Boehner, would only say Tuesday that the party's steering committee chaired by the speaker made the decision "based on a range of factors."

Groups aligned with the tea party movement were generally big supporters of Huelskamp, Amash and Schweikert. Jones is viewed more as a conservative maverick than a tea party Republican. He has frequently siding against GOP leaders on a range of issues over the years. For example, he voted against the GOP budget because he opposed the changes proposed for Medicare.

Schweikert said it was made clear to him "I should vote for the team more."

"Look, we're walking into the 113th Congress with a smaller majority," Schweikert said. "I would have though the fixation would have been family unity. This isn't the way you start a family meeting."

"The GOP leadership might think they have silenced conservatives, but removing me and others from key committees only confirms our conservative convictions," Huelskamp said in a statement Tuesday. "This is clearly a vindictive move and a sure sign that the GOP establishment cannot handle disagreement."

All four lawmakers had voted against the summer 2011 deal negotiated between Republican leaders and President Barack Obama for extending the government's ability to borrow money in exchange for $1 trillion in spending cuts and the promise of another $1 trillion in reduced deficits. Three of the four, the exception being Schweikert, voted against the Ryan-written GOP budget blueprint that the House passed last March.

Their removal from key committees with jurisdiction over the two issues was viewed by some as a signal to other Republican lawmakers to look favorably on whatever final deal Boehner and Obama put together to avert a "fiscal cliff" combination of automatic tax increases and spending cuts in January.

"It's sending a clear message to get behind the leadership no matter what the policy is, and that is contrary to what the Republicans supposedly stand for," Freedomworks' Kibbe said.

"If it was intended to be a signal, it's going to be a weak signal because the majority of conservatives are going to do what they think is right based on principle," Jones, the North Carolina congressman, said.

Amash said he has not been told specifically why he was removed, only that it was not based on his votes and that he should go talk to leadership. He said he voted with the Budget Committee's leadership 95 percent of the time. He said the move is likely to make him more independent in the future.

"Being nice to leadership and playing well with them doesn't pay off," Amash said. "They expect a near total agreement with their approach."

The changes in committee assignments could bring about more discipline from the GOP on high-priority issues next Congress, but conservatives were taking the news as an attack on their priorities.

"As the sun rises this morning we can look at John Boehner, Eric Cantor and Kevin McCarthy and know the opposition is not just across the aisle, but in charge of our own side in the House of Representatives," Erick Erickson wrote on the conservative website, RedState. "All the time and energy I would otherwise have to spend to convince conservatives that these gentlemen would be a problem for the GOP has been spared. They've proven it themselves."

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Official: Syria moving chemical weapons components

WASHINGTON (AP) — U.S. and allied intelligence have detected Syrian movement of chemical weapons components in recent days, a senior U.S. defense official said Monday, as the Obama administration strongly warned the Assad regime against using them.

A senior defense official said intelligence officials have detected activity around more than one of Syria‘s chemical weapons sites in the last week. The defense official spoke on condition of anonymity because he was not authorized to speak publicly about intelligence matters.

Secretary of State Hillary Rodham Clinton, in Prague for meetings with Czech officials, reiterated President Barack Obama‘s declaration that Syrian action on chemical weapons was a “red line” for the United States that would prompt action.

“We have made our views very clear: This is a red line for the United States,” Clinton told reporters. “I’m not going to telegraph in any specifics what we would do in the event of credible evidence that the Assad regime has resorted to using chemical weapons against their own people. But suffice it to say, we are certainly planning to take action if that eventuality were to occur.”

Syria said Monday it would not use chemical weapons against its own people. The Ministry of Foreign Affairs said Syria “would not use chemical weapons — if there are any — against its own people under any circumstances.”

Syria has been careful never to confirm that it has any chemical weapons.

The use of chemical weapons would be a major escalation in Assad’s crackdown on his foes and would draw international condemnation. In addition to causing mass deaths and horrific injuries to survivors, the regime’s willingness to use them would alarm much of the region, particularly neighboring states, including Israel.

At the White House, press secretary Jay Carney said, “We are concerned that in an increasingly beleaguered regime, having found its escalation of violence through conventional means inadequate, might be considering the use of chemical weapons against the Syrian people. And as the president has said, any use or proliferation of chemical weapons by the Syrian regime would cross a red line for the United States. “

Administration officials would not detail what that response might be.

Although Syria is one of only seven nations that have not signed the Chemical Weapons Treaty, it is a party to the 1925 Geneva Protocol that bans the use of chemical weapons in war. That treaty was signed in the aftermath of World War I, when the effects of the use of mustard gas and other chemical agents outraged much of the world.

Clinton didn’t address the issue of the fresh activity at Syrian chemical weapons depots, but insisted that Washington would address any threat that arises.

An administration official said the trigger for U.S. action of some kind is the use of chemical weapons or movement with the intent to use or provide them to a terrorist group like Hezbollah. The U.S. is trying to determine whether the recent movement detected in Syria falls into any of those categories, the official said. The administration official was speaking on condition of anonymity this person was not authorized to speak publicly about the issue.

The senior defense official said the U.S. does not believe that any Syrian action beyond the movement of components is imminent.

An Israeli official said if there is real movement on chemical weapons, it would require a response. He didn’t say what that might be and spoke on condition of anonymity pending a formal government response to the reports of the latest activities.

Israeli officials have repeatedly expressed concerns that Syrian chemical weapons could slip into the hands of Hezbollah or other anti-Israel groups, or even be fired toward Israel in an act of desperation by Syria.

Syria is believed to have several hundred ballistic surface-to-surface missiles capable of carrying chemical warheads.

Its arsenal is a particular threat to the American allies, Turkey and Israel, and Obama singled out the threat posed by the unconventional weapons earlier this year as a potential cause for deeper U.S. involvement in Syria’s civil war. Up to now, the United States has opposed military intervention or providing arms support to Syria’s rebels for fear of further militarizing a conflict that activists say has killed more than 40,000 people since March 2011.

Clinton said that while the actions of President Bashar Assad‘s government have been deplorable, chemical weapons would bring them to a new level.

“We once again issue a very strong warning to the Assad regime that their behavior is reprehensible, their actions against their own people have been tragic,” she said. “But there is no doubt that there’s a line between even the horrors that they’ve already inflicted on the Syrian people and moving to what would be an internationally condemned step of utilizing their chemical weapons.”

Activity has been detected before at Syrian weapons sites, believed to number several dozen.

Defense Secretary Leon Panetta said in late September the intelligence suggested the Syrian government had moved some of its chemical weapons in order to protect them. He said the U.S. believed that the main sites remained secure.

Asked Monday if they were still considered secure, Pentagon press secretary George Little declined to comment about any intelligence related to the weapons.

Senior lawmakers were notified last week that U.S. intelligence agencies had detected activity related to Syria’s chemical and biological weapons, said a U.S. intelligence official, speaking on condition of anonymity to discuss the closed-door meetings. All congressional committees with an interest in Syria, from the intelligence to the armed services committees, are now being kept informed.

“I can’t comment on these reports but I have been very concerned for some time now about Syria’s stockpiles of chemical weapons and its stocks of advanced conventional weapons like shoulder-launched anti-aircraft missiles,” said House intelligence committee Chairman Mike Rogers, R-Mich. “We are not doing enough to prepare for the collapse of the Assad regime, and the dangerous vacuum it will create. Use of chemical weapons by the Assad regime would be an extremely serious escalation that would demand decisive action from the rest of the world,” he added.

Syria is believed to have one of the world’s largest chemical weapons programs, and the Assad regime has said it might use the weapons against external threats, though not against Syrians. The U.S. and Jordan share the same concern about Syria’s chemical and biological weapons — that they could fall into the wrong hands should the regime in Syria collapse and lose control of them.

___

Klapper reported from Prague. Associated Press writers Josef Federman in Jerusalem, Albert Aji in Damascus and Matthew Lee, Kimberly Dozier, and Julie Pace in Washington contributed to this report.

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UK’s Prince William and wife Kate expecting a baby

LONDON (Reuters) – Britain‘s Prince William and his wife Catherine are expecting a baby, destined to be the country’s future monarch, although the mother-to-be is in hospital with a type of very acute morning sickness that sometimes indicates twins.

“Their Royal Highnesses The Duke and Duchess of Cambridge are very pleased to announce that The Duchess of Cambridge is expecting a baby,” the prince’s office said in a statement on Monday, adding that Queen Elizabeth and the royal family were delighted.

The couple, officially known as the Duke and Duchess of Cambridge, married in April last year, amid a global media frenzy and there has been much speculation, particularly in U.S. gossip magazines, about a possible pregnancy.

“It’s only been a matter of time. Everyone has been waiting for Kate to announce that she was pregnant,” Claudia Joseph, who has written a biography of the duchess, told Reuters.

A spokeswoman for the couple said 30-year-old Catherine, widely known as Kate, was in the King Edward VII Hospital in central London suffering from Hyperemesis Gravidarum, an acute morning sickness which causes severe nausea and vomiting and requires supplementary hydration and nutrients.

Professor Tim Draycott, a consultant obstetrician at the University of Bristol, said the condition was common in the early weeks of pregnancy but did not put the baby at any increased risk, although in extreme cases it can lead to the baby being born with a slightly low birth weight.

Draycott told Reuters it may also indicate more than one royal baby may be in the offing.

“Hyperemesis is slightly more common with twins,” said Draycott, explaining that the condition affected around one in 100 to 200 pregnant women.

William, a Royal Air Force helicopter pilot, was at her side and she is likely to remain in hospital for several days. There was no detail about when the baby was due, although the prince’s spokesman said she was less than 12 weeks pregnant.

“I’m delighted by the news that the Duke and Duchess of Cambridge are expecting a baby,” Prime Minister David Cameron said on his Twitter website. “They will make wonderful parents.”

BABY WILL BE KING, OR QUEEN

William, Queen Elizabeth’s 30-year-old grandson, is second in line to the British throne, and their first child will become the third in succession when he or she is born.

Last year Britain and other Commonwealth countries which have the queen as their monarch agreed to change the rules of royal succession so that males would no longer have precedence as heir, regardless of age.

The agreement also means an end to a ban on a future monarch marrying a Catholic, a stipulation dating back some 300 years.

Britain’s royal family are currently riding the crest of popularity on the back of William and Kate‘s wedding and the queen’s diamond jubilee this year which has witnessed nationwide celebrations.

“It’s something everyone can look forward to, just like their wedding brought the whole nation together,” said Johanna Castle, 25, a sales assistant in an east London homewear and fashion store.

The young royal couple have become global stars after some two billion people tuned in to watch their glittering marriage ceremony and the sumptuous display of pageantry that accompanied it, and barely a day goes by without a picture of Catherine appearing in the pages of Britain‘s royalty-obsessed newspapers.

The duchess, the first “commoner” to marry a prince in close proximity to the throne in more than 350 years, is now a fashion icon, with her attire scrutinized every time she steps out in public and followed by legions of women around the world.

U.S. President Barack Obama and his wife Michelle were one of the first to send congratulations, an indication of the young royals’ popularity across the Atlantic.

“I know they both feel that having a child is one of the most wonderful parts of their lives. So I’m sure that will be the same for the Duke and Duchess of Cambridge,” said White House spokesman Jay Carney.

With their fame has come unwanted attention, and there was anger in Britain when topless photos of Kate relaxing on holiday were published in a French magazine in September.

The pictures rekindled memories of the media pursuit of William’s mother, Princess Diana, who was killed in a car crash in Paris in 1997 while being chased by paparazzi.

“I will be very surprised if this isn’t handled with the utmost tact and sensitivity,” said media commentator Steve Hewlett. “Newspapers realize there’s a huge amount of goodwill towards Will and Kate, and they take their cue from their readers.”

“DADDY’S LITTLE CO-PILOT”

Kate made her last public appearance on Friday when she returned to her old school – a minor event that nonetheless generated live television coverage on news channels – when she looked healthy and joined in a game of hockey with pupils.

Earlier in the week William had hinted at a pregnancy during a visit to Cambridge in central England when they were given a home-made baby suit emblazoned with the words “Daddy’s little co-pilot”, a reference to William’s job.

“When I gave it to him he said ‘I’ll keep that’, and handed it to his aide,” said Samantha Hill.

Joseph, author of “Kate: The Making of a Princess”, said she believed the couple, who currently live in north Wales where the prince is based as a search and rescue pilot, had been waiting for the right moment to have a baby.

“My feeling has always been that they were not going to take the spotlight away from the queen in her Jubilee. But now 2013 is going to be William and Kate’s year,” she said, adding the couple would make wonderful parents.

“We have seen her with children and she is lovely with them, she’s got the natural touch, and her parents run a party business and she has spent a lot of time with children,” Joseph said. “(William) he has always talked about wanting children, so I am sure he is delighted.”

(Additional reporting by Tim Castle, Peter Schwartzstein and Natalie Huet in London and Steve Holland in Washington; editing by Paul Casciato)

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